Protheragen-ING Lab provides comprehensive pharmaceutical physical/chemical analysis services, specializing in the accurate and reliable assessment of relative density. Our state-of-the-art laboratory and experienced team ensure that your pharmaceutical products meet the highest quality standards and regulatory requirements.
What is relative density?
Relative Density, also known as specific gravity, is a crucial parameter in the pharmaceutical industry. It is the ratio of the density of a substance to the density of a reference substance, typically water. This measurement is essential for ensuring the consistency and quality of liquid formulations, suspensions, and other pharmaceutical products.
- Quality Control: Ensures the consistency of product formulations.
- Compliance: Meets regulatory requirements for pharmaceutical manufacturing.
- Product Stability: Assesses the stability and uniformity of liquid products.
- Dosage Accuracy: Ensures the correct dosage of active ingredients.
Protheragen-ING Lab's testing services
- Sample Preparation: Our team follows rigorous protocols to prepare samples, ensuring accurate and reproducible results.
- Measurement Techniques: We utilize advanced techniques and equipment, such as pycnometers, digital density meters, and hydrometers, to determine the relative density of your samples with precision.
- Data Analysis: Our experts analyze the data meticulously, providing detailed reports that include all necessary calculations and observations.
- Regulatory Compliance: We ensure that all tests are performed in accordance with the latest pharmacopeial standards and regulatory guidelines, including USP, EP, and JP.
Factors Affecting Relative Density Measurement
Accurate measurement of relative density is essential for ensuring the quality and consistency of pharmaceutical products. Several factors can influence the accuracy of these measurements. Protheragen-ING Lab takes all these factors into account to provide precise and reliable relative density measurements.
Temperature
Temperature variations can cause expansion or contraction of the sample and the reference fluid, leading to inaccurate density readings.
We Conduct measurements at a controlled temperature or use temperature compensation techniques.
Purity of the Sample
Effect: Impurities in the sample can alter its density, resulting in erroneous relative density values.
We ensure samples are free from contaminants and impurities through proper sample preparation.
Sample Handling
Mishandling samples, such as introducing air bubbles or not mixing properly, can affect density measurements.
We follow standardized sample handling procedures to minimize errors.
Testing methods for relative density
Protheragen-ING Lab employs a variety of precise and reliable methods to determine the relative density of pharmaceutical products. Each method is selected based on the specific characteristics of the sample and the required accuracy.
Here are the primary methods we use:
| / | Overview | Procedure | Applications |
| Pycnometer Method | A pycnometer is a precise glass flask used to measure the density of liquids. | The pycnometer is first weighed empty, then filled with the sample and reweighed. The density is calculated by measuring the mass and volume of the sample. |
Ideal for highly viscous liquids and small sample quantities. |
| Digital Density Meter | A digital density meter uses oscillating U-tube technology to measure the density of liquids. | The sample is injected into the U-tube, which oscillates at a specific frequency. The density is determined based on the change in oscillation frequency caused by the sample. |
Suitable for routine analysis and quality control in pharmaceutical laboratories. |
| Hydrometer Method | A hydrometer is a simple device that measures the density of a liquid by floating in the sample. | The hydrometer is gently placed in the sample, and the level at which it floats is noted. The density is read directly from the calibrated scale on the hydrometer. |
Useful for quick, on-site density measurements. |
| Hydrostatic Weighing | Hydrostatic weighing involves measuring the buoyancy of an object immersed in a liquid. | The sample is weighed in air and then submerged in a reference liquid (typically water). The density is calculated based on the weight difference. |
Suitable for measuring the density of solid pharmaceutical forms and powders. |
| Oscillating U-tube Method | This method uses the principle of an oscillating U-tube filled with the sample to determine density. | The U-tube containing the sample is set to oscillate at its natural frequency. The frequency change caused by the sample's mass is used to calculate its density. |
Ideal for high-throughput laboratories requiring rapid and accurate density measurements. |
Contact us today to learn more about our relative density test services and how we can assist you in achieving your quality assurance goals.