An ISO9001 Certified Supplier of Pre-Clinical Contract Research Service and Analytical Service
Welcome to our immunotoxicology testing service, Protheragen-ING Lab specializes in immunotoxicology studies of various compounds. Using advanced techniques such as cellular and humoral immunoreactivity, we can help you understand the immunotoxicology of your drug compounds so that potentially immunotoxic drugs can be predicted early in the drug development process. Whether you are a pharmaceutical company, a regulatory agency, or a research organization, we are here to meet your needs for evaluating the immunosafety of your drug compounds.
Significance of immunotoxicology research
Immunotoxicology is a branch of toxicology that focuses on the adverse effects of chemical substances on the immune system. The immune system plays a vital role in protecting the body from foreign substances, pathogens, and abnormal cells. However, exposure to certain chemicals or drugs may disrupt the normal functioning of the immune system. Understanding the potential immunotoxic effects of compounds is essential to ensure the safety of drugs, chemicals and other products.
Research capabilities of Protheragen-ING Lab
We have extensive research capabilities to assess the immunotoxicity of compounds. Our expertise includes evaluating the following immunotoxicological effects:
- Immunosuppression - We study the potential of pharmaceutical compounds to suppress the immune system. Subjects may be immunocompromised and can break down into responsible cellular compartments.
- Immunogenicity - We assess the ability of a drug, its metabolites, excipients, or contaminants to induce an immune response to be.
- Hypersensitivity - We assess the potential of a drug, its metabolite, excipient, or contaminant to trigger an allergic or hypersensitivity reaction by examining immune-mediated responses such as IgE production or histamine release.
- Adverse Immune Stimulation - We examine the potential of a subject to cause excessive or inappropriate immune activation leading to inflammation and tissue damage by activating immune effector mechanisms through multiple pathways.
Our standardized immunotoxicity testing solutions
Our state-of-the-art facilities and experienced team of scientists are dedicated to providing comprehensive and reliable immunotoxicity testing solutions. We employ a variety of in vitro and in vivo techniques to assess the immunotoxicological effects of compounds. These include cell-based assays, animal models, flow cytometry, cytokine analysis, histopathology analysis, and more. We ensure that our testing methods comply with regulatory guidelines and industry standards.
Humoral Immunity
We evaluate the effects of drug compounds on antibody production, including measurements of antigen-specific antibody levels, B-cell function and humoral immune responses.
- Serum globulin levels and Albumin to Globulin (A/G) ratio.
- Immunoglobulin isotype distribution of IgM, IgG, IgA, and IgE.
- Total hemolytic complement activity and complement composition.
- Immunochemical determination of serum cytokines.
- Serum autoantibody screening and immunoglobulin deposition.
Cellular Immunity
We evaluate the effects of the subjects on cell-mediated immune responses, including T-cell proliferation and activation, natural killer (NK) cell activity, cytokine production, and antigen-specific immune responses.
- Immunostaining and flow cytometry analysis of B cells, T cells and T cell subpopulations.
- Mitotic stimulation assays for B cells and T cells.
- NK cell activity.
- Macrophage and neutrophil function assays.
Contact us today to discuss your immunotoxicology testing needs and how we can help you ensure compound safety.