An ISO9001 Certified Supplier of Pre-Clinical Contract Research Service and Analytical Service
Pharmaceutical chemical and physical analyses are used to analyze the chemical and physical properties of drug substances, pharmaceutical products and related materials. These analyses are essential to ensure the quality, safety and efficacy of pharmaceutical products throughout the development, manufacturing and distribution processes.
Protheragen-ING Lab offers comprehensive physical/chemical analysis services tailored specifically for the pharmaceutical industry to support formulation, process development, quality control, batch release testing and investigational manufacturing troubleshooting. Our state-of-the-art facilities and highly skilled team ensure accurate and reliable results to meet regulatory requirements.
Sample types that Protheragen-ING Lab can test
We have extensive experience with a range of product types, from raw materials to active pharmaceutical ingredients, and can adapt to virtually any product type, including but not limited to:
- Raw material.
- Development materials.
- intermediate work in progress.
- active pharmaceutical ingredients.
- Stability study sample.
- unknown for identification or confirmation.
Find out more about each of our services
We can provide you with the following pharmaceutical physical/chemical analysis programs, including but not limited to:
Relative Density
The determination of relative density provides information about the density of a pharmaceutical substance or product compared to the density of a reference material. It is an important parameter for quality control and formulation development.
Melting Point
The measurement of the melting point is crucial for characterizing pharmaceutical substances and verifying their identity. It helps identify impurities, assess purity, and determine the appropriate storage conditions.
Optical Rotation
Optical rotation analysis determines the rotation of plane-polarized light by a pharmaceutical compound. It is used to assess the purity and chiral nature of certain drugs and to monitor the quality and consistency of pharmaceutical formulations.
Refractive Index
The refractive index is a fundamental property that characterizes the light-bending ability of a substance. It is utilized in pharmaceutical analysis to determine the concentration of active ingredients, assess purity, and identify unknown substances.
LogP/LogD/pKa
LogP, LogD, and pKa are parameters related to the physicochemical properties of pharmaceutical compounds. LogP measures the lipophilicity, LogD indicates the distribution between octanol and water, and pKa represents the acidity or basicity. These values are critical for predicting drug absorption, distribution, metabolism, and excretion (ADME) properties.
pH
pH measurement is essential for assessing the acidity or alkalinity of pharmaceutical solutions, suspensions, and emulsions. It is a key parameter in formulation development, stability testing, and drug delivery systems.
Molar Concentration and Osmotic Pressure
Determining the molar concentration and osmotic pressure of pharmaceutical solutions provides information about their solute concentration and the resulting colligative properties. These analyses are crucial for parenteral formulations, isotonicity assessment, and drug delivery systems.
Viscosity
Viscosity analysis measures the resistance of a pharmaceutical liquid or semi-solid formulation to flow. It is essential for assessing product stability, dosage form development, and ensuring proper manufacturing processes.
Electrical Conductivity
Electrical conductivity analysis evaluates the ionic strength or conductivity of pharmaceutical solutions. It is used in the quality control of electrolyte solutions and pharmaceutical products containing ions.
Total Organic Carbon
TOC analysis quantifies the amount of organic carbon present in a pharmaceutical sample. It is employed to assess the cleanliness of equipment, detect residual solvents, and monitor water quality in pharmaceutical manufacturing processes.
Particle Size and Particle Morphology
Particle size analysis determines the size distribution and shape characteristics of pharmaceutical particles. This information is critical for assessing product performance, optimizing formulation, and ensuring consistent drug delivery.
Particle Surface Charge
Particle surface charge analysis measures the zeta potential of pharmaceutical particles, which indicates their electrostatic properties. It helps understand particle stability, dispersion behavior, and potential interactions with biological systems.
Disintegration
Disintegration testing evaluates the breakdown of solid dosage forms, such as tablets and capsules, into smaller particles when exposed to a physiological fluid. It is a critical test for assessing drug release and bioavailability.
Dissolution
Dissolution testing measures the rate of drug release from solid dosage forms and its subsequent dissolution in a simulated physiological fluid. It is crucial for assessing drug performance, formulation optimization, and ensuring bioequivalence between generic and innovator products.
At our laboratory, we adhere to strict quality control measures, follow validated methods, and provide comprehensive reports with accurate and reliable results. Our experienced team is committed to delivering high-quality analysis that meets your specific pharmaceutical requirements.
Contact us today to learn more about our pharmaceutical physical/chemical analysis services and how we can assist you in navigating the complex landscape of drug development.