Protheragen-ING Lab is committed to delivering precise and reliable melting point data to support your pharmaceutical development and quality control processes. Our team is dedicated to ensuring the highest standards of accuracy and professionalism in every analysis we perform.
Melting point of drugs
The melting point of a pharmaceutical is a key physical property that indicates the temperature at which a substance changes from a solid to a liquid state. When determining the melting point, the temperature is usually recorded as a melting range rather than an exact melting point because most samples appear to melt within a small temperature range. The melting range is the difference between the temperature at which a sample begins to melt and the temperature at which it actually melts.
This parameter is critical to understanding the purity, stability, and identity of a pharmaceutical compound. Accurately determining the melting point can reveal the presence of impurities and ensure that the drug meets the required quality standards.
Our drug melting point testing services
At Protheragen-ING Lab, we provide comprehensive melting point testing services tailored to the needs of the pharmaceutical industry. Our state-of-the-art laboratory is equipped with advanced instrumentation to deliver accurate and reliable melting point measurements. Our experienced team of scientists follows stringent protocols to ensure that all results are precise and reproducible.
Precautions when testing the melting point
When testing the melting point of a drug, several precautions must be taken to guarantee the accuracy and reliability of the results:
- Sample Preparation: Ensure the sample is finely powdered and free from contaminants. Impurities can alter the melting point and lead to erroneous conclusions.
- Instrument Calibration: Regular calibration of the melting point apparatus is essential to maintain accuracy. Use certified reference materials for calibration purposes.
- Controlled Environment: Perform the test in a controlled environment to minimize the influence of external factors such as humidity and temperature fluctuations.
- Consistent Heating Rate: Use a consistent and appropriate heating rate to avoid superheating or rapid melting, which can affect the determination of the exact melting point.
- Replicate Measurements: Conduct multiple measurements to ensure reproducibility and reliability of the results.
Our drug melting point testing methods
We employ several advanced methods for determining the melting point of pharmaceutical compounds:
Capillary Method
This traditional method involves placing a small amount of the powdered sample in a thin-walled capillary tube, which is then heated in a controlled manner. The temperature at which the sample transitions from solid to liquid is recorded as the melting point.
Differential Scanning Calorimetry (DSC)
DSC is a highly sensitive technique that measures the heat flow associated with phase transitions. It provides detailed information about the melting behavior, including the exact melting point and the enthalpy of fusion.
Hot Stage Microscopy
This technique combines microscopy with controlled heating to observe the melting process directly. It is particularly useful for identifying polymorphic forms and analyzing small sample quantities.
For more information or to request our melting point testing services, please contact us.